Skeletal Muscle Function in Patients with Diabetes

Skeletal Muscle Mitochondrial Function/Dysfunction and Type 2 Diabetes

Skeletal muscle mitochondrial dysfunction & diabetes.

Skeletal muscle insulin resistance is a key contributor to the pathophysiology of type 2 diabetes. Recent studies have shown that insulin resistance in a variety of conditions including type 2 diabetes, ageing and in offspring of type 2 diabetes is associated with muscle mitochondrial dysfunction. The important question is whether insulin resistance results from muscle mitochondrial dysfunction...

Decreased β-Cell Function Is Associated with Reduced Skeletal Muscle Mass in Japanese Subjects without Diabetes

BACKGROUND Decreased insulin secretion has a great impact on the incidence of type 2 diabetes in Japanese subjects. It is not clear whether β-cell function is related to muscle mass in subjects without diabetes. We investigated the relationship between β-cell function and skeletal muscle mass in Japanese subjects without diabetes. METHODS The study included 1098 subjects (538 men and 560 wome...

Skeletal muscle dysfunction vs. muscle disuse in patients with COPD.

Maltais, François, Jean Jobin, Martin J. Sullivan, Sarah Bernard, François Whittom, Kieran J. Killian, Marc Desmeules, Marthe Bélanger, and Pierre LeBlanc. Metabolic and hemodynamic responses of lower limb during exercise in patients with COPD. J. Appl. Physiol. 84(5): 1573–1580, 1998.—Premature lactic acidosis during exercise in patients with chronic obstructive pulmonary disease (COPD) may pl...

Lower limb skeletal muscle function

Berg, H. E., L. Larsson, and P. A. Tesch. Lower limb skeletal muscle function after 6 wk of bed rest. J. Appl. Physiol. 82(1): 182–188, 1997.—Force, electromyographic (EMG) activity, muscle mass, and fiber characteristics were studied in seven healthy men before and after 6 wk of bed rest. Maximum voluntary isometric and concentric knee extensor torque decreased (P , 0.05) uniformly across angu...